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New Weight Loss Drug Shows Positive Results In Testing

Ryan | August 3rd, 2012

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A new weight loss drug being tested on mice could potentially help people not only lose weight, but maintain weight loss for the long term. Known at this stage only as JD5037, the drug is an appetite suppressant, a category of drug that makes patients feel less hungry when they’re not eating, and more full when they are. Appetite suppressants are often prescribed by physicians to type 2 diabetes patients who are looking to treat their condition by following a diabetes diet plan.

Though JD5037 has yet to be tested on humans, or submitted to the Food and Drug Administration, if the drug were to be approved it would likely become another tool in the arsenal of patients and doctors looking to reverse type 2 diabetes by following a safe weight loss diet to reduce diabetes.

Researchers who studied the new drug report that obese mice who took it ate less, lost more weight, and showed decreased insulin resistance than mice who did not take the drug.

New weight loss drug blocks receptors

The drug seems to function by increasing the body’s receptiveness to leptin, a hormone that diminishes the appetite. Obese people often become desensitized to liptin.

“By sensitizing the body to naturally occurring leptin, the new drug could not only promote weight loss, but also help mainatain it,” concludes George Kunos, one of the study researchers.

When cannabinoid receptors are activated in the body, appetite increases. The chemicals in marijuana, for instance, are known to activate these receptors. Blocking cannabinoid receptors suppresses feelings of hungers, which leads to less caloric intake, and weight loss.

In 2006, a weight loss drug called rimonabant, which also worked by blocking cannabinoid receptors, was introduced to the European market. It was recalled only a few years later due to serious psychiatric side effects, such as depression, anxiety, and suicidal thoughts.

Researchers studying JD5037 are hopeful that because the drug does not enter the brain, but instead only blocks cannabinoid receptors in the liver and muscle, that it will not lead to similar psychiatric side effects once it is tested on humans.

Diabetes diet for weight loss

Many people with type 2 diabetes can improve or even completely reverse their condition through a healthy program of diet and exercise. The Center For Medical Weight Loss, the largest group of weight loss physicians in the country, has produced thousands of successful weight loss stories, many involving patients following a diabetes diet.

“We see diabetic patients all the time who lose weight and no longer need insulin,” reports Dr. Michael Kaplan, founder and chief medical officer of The Center for Medical Weight Loss. “When patients lose 5% – 10% of their body weight, it is a given that they will reduce their blood sugar significantly; many no longer need medication.”

The Center For Medical Weight Loss operates 450 centers throughout the Untied States. Use the zip code search box above to see if there is a location near you. Introductory offers are available for first-time visitors at select centers.